Clinical Characteristics and Prognosis of Differentiated Thyroid Carcinoma with Small Foci of Anaplastic Transformation
International Journal of Thyroidology
;
: 96-101, 2017.
Article
in English
| WPRIM
| ID: wpr-155533
ABSTRACT
BACKGROUND AND OBJECTIVES:
Anaplastic thyroid carcinoma (ATC) is commonly related with concurrent differentiated thyroid carcinoma (DTC). We aimed to examine the clinicopathologic characteristics, prognosis and gene expression of DTC with anaplastic foci. MATERIALS ANDMETHODS:
Eighteen patients with DTC with anaplastic foci were enrolled in this study. To compare the clinicopathologic characteristics and prognosis of anaplastic foci subjects with conventional ATC or DTC, we additionally included 12 ATC and 1030 DTC patients who diagnosed during same period. Immunohistochemistry was performed to check the gene expression in anaplastic foci and DTC component.RESULTS:
In anaplastic foci group, tumor size was larger (2.5±1.3 vs. 1.2±0.9 cm, p=0.001), distant metastasis was more frequent (11.1 vs. 0%, p=0.000) and 1-year survival rate was low (88.9 vs. 100%, p=0.000) than DTC group. In contrast, compared with ATC group, anaplastic foci group showed younger age at diagnosis (50±16 vs. 63±18 years, p=0.039), smaller tumor size (2.5±1.3 vs. 3.8±1.4 cm, p=0.027), less distant metastasis (11.1 vs. 41.7%, p=0.084) and longer 1-year survival rate (88.9 vs. 25.0%, p=0.001). Expression of p53 protein was observed in 100% of anaplastic foci, ATC and 12.5% of papillary thyroid carcinoma component.CONCLUSION:
DTC with foci of anaplastic transformation has a worse prognosis than DTC, but a better prognosis than ATC. Our results support that DTC with anaplastic foci was intermediate state from DTC to ATC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Thyroid Gland
/
Thyroid Neoplasms
/
Immunohistochemistry
/
Gene Expression
/
Survival Rate
/
Tumor Suppressor Protein p53
/
Diagnosis
/
Thyroid Carcinoma, Anaplastic
/
Neoplasm Metastasis
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
International Journal of Thyroidology
Year:
2017
Type:
Article
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