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A Case of Myeloid Neoplasm with a PDGFRB Rearrangement and Eosinophilia / 대한내과학회지
Korean Journal of Medicine ; : 79-83, 2017.
Article in Korean | WPRIM | ID: wpr-155824
ABSTRACT
Myeloid neoplasia with eosinophilia and platelet-derived growth factor receptor beta (PDGFRB) rearrangements is an uncommon Philadelphia-negative myeloproliferative neoplasm. Their most common morphological diagnosis is chronic myelomonocytic leukemia with eosinophilia, which is associated with t(5;12)(q33;p13) and results in the formation of the ETV6-PDGFRB fusion gene. Here, we report a 49-year-old man with a myeloid neoplasm with a PDGFRB rearrangement, who was incidentally diagnosed with hyperleukocytosis and eosinophilia during a health screening. A chromosome analysis of a bone marrow sample revealed 46, XY, t(5;12)(q33;p13), and fluorescence in situ hybridization analysis revealed the PDGFRB gene rearrangement. The patient was treated with imatinib and subsequently achieved complete hematological and molecular remission.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone Marrow / Gene Rearrangement / Leukemia, Myelomonocytic, Chronic / Mass Screening / Receptors, Platelet-Derived Growth Factor / In Situ Hybridization / Receptor, Platelet-Derived Growth Factor beta / Diagnosis / Eosinophilia / Fluorescence Type of study: Diagnostic study / Prognostic study / Screening study Limits: Humans Language: Korean Journal: Korean Journal of Medicine Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone Marrow / Gene Rearrangement / Leukemia, Myelomonocytic, Chronic / Mass Screening / Receptors, Platelet-Derived Growth Factor / In Situ Hybridization / Receptor, Platelet-Derived Growth Factor beta / Diagnosis / Eosinophilia / Fluorescence Type of study: Diagnostic study / Prognostic study / Screening study Limits: Humans Language: Korean Journal: Korean Journal of Medicine Year: 2017 Type: Article