Chemotherapy in Lung Cancer
Journal of the Korean Medical Association
;
: 38-45, 2003.
Article
in Korean
| WPRIM
| ID: wpr-156097
ABSTRACT
Non-small cell lung cancer As most patients with non-small cell lung cancer present with nonsurgically curable diseae, major efforts have been made in the treatment of advanced non-small cell lung cancer (NSCLC) with chemotherapy. Controlled studies of platinum-based chemotherapy vs. supportive care showed statistically significant improvements in survival. During the last several years, the introduction of several new chemotherapeutic agents, such as the taxanes, gemcitabine, vinorelbine, and irinotecan has resulted in improved survival and quality of life for patients with advanced NSCLC. However, the superiority of a regimen in terms of improved survival, quality of life, and toxicity profile has still remained unclear. Newer, targeted therapies hold promise to improve outcome without adding a great deal of additional toxicity. Small cell lung cancer Small cell lung cancer (SCLC) is characterized by early dissemination and a rapid, aggressive clinical course. The role of combination chemotherapy in patients with SCLC was well established since 1970's; however, no trend toward longer survival has been observed during the last decade. Even if the use of adjunctive radiation therapy does not help in extending survival in extensive-disease, the use of chemotherapy without radiation therapy is to be discouraged in patients with limited-disease, because randomized trials showed a definite survival advantage for combined modality therapy. In terms of the choice of chemotherapy, etoposide/cisplatin or etoposide/carboplatin have emerged as the regimens of choice because they offer a good therapeutic index and can be combined with radiotherapy. Recently, several active agents such as taxanes, topotecan, vinorelbine, and irinotecan have been used in SCLC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Radiotherapy
/
Combined Modality Therapy
/
Carcinoma, Non-Small-Cell Lung
/
Topotecan
/
Taxoids
/
Drug Therapy
/
Drug Therapy, Combination
/
Small Cell Lung Carcinoma
/
Lung
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Medical Association
Year:
2003
Type:
Article
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