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Topiramate Monotherapy in Infantile Spasm
Yonsei Medical Journal ; : 498-504, 2006.
Article in English | WPRIM | ID: wpr-156140
ABSTRACT
Infantile spasm is an age-related refractory epilepsy. Topiramate is a new anticonvulsant with multiple mechanisms of action, and it may be effective for treating pediatric epilepsies. To evaluate the efficacy and tolerability of first-line topiramate treatment for infantile spasm, 20 patients received topiramate monotherapy during this study. They were treated with an initial dose of 1mg/kg/day, with a progressive titration of 1 mg/kg a week until their spasms were controlled and a maximum dose of 12mg/kg/day was achieved. The evaluation of the treatment efficacy was based on the spasm frequency data that was obtained by the scalp and video-EEG, and by the parental count of spasm. Thirty percent of the subjects became spasm-free during the study. Six of 20 subjects (30%) had cessation of spasm and disappearance of hypsarrhythmia as seen via the video EEG; four (50%) of eight idiopathic patients had a response, whereas two (17%) of 12 patients with symptomatic infantile spasm responded. Seventy of the patients, including the spasm-free patients, had a reduction in their seizure frequency of more than 50%, and 10% of the patients had a reduction in their seizure frequency of less than 50%. The clusters of spasm frequency decreased from 10.6 +/- 8.5 to 3.5 +/- 1.4 clusters/day. Topiramate is effective and tolerated in those patients suffering from infantile spasm. Our results suggest that this drug should be considered as a new first-line drug for treating infantile spasm.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spasms, Infantile / Treatment Outcome / Age of Onset / Electroencephalography / Fructose / Anticonvulsants Limits: Child, preschool / Female / Humans / Infant / Male Language: English Journal: Yonsei Medical Journal Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spasms, Infantile / Treatment Outcome / Age of Onset / Electroencephalography / Fructose / Anticonvulsants Limits: Child, preschool / Female / Humans / Infant / Male Language: English Journal: Yonsei Medical Journal Year: 2006 Type: Article