Clinical and Radiographic Characteristics of 12 Patients with Mycobacterium abscessus Pulmonary Disease / 결핵
Tuberculosis and Respiratory Diseases
;
: 45-56, 2003.
Article
in Korean
| WPRIM
| ID: wpr-156255
ABSTRACT
BACKGROUND:
Mycobacterium abscessus is the most common respiratory pathogen in rapidly growing mycobacteria and is resistant to all of the first-line antituberculosis drugs. This report describes the clinical and radiographic characteristics in patients with pulmonary disease caused by M. abscessus. MATERIALS ANDMETHODS:
Twelve patients with pulmonary disease caused by M. abscessus who fulfilled the 1997 American Thoracic Society diagnostic criteria for a nontuberculous mycobacterial pulmonary infection were observed over a five-and-a-half year period. The clinical characteristics and chest radiographic findings were analyzed, retrospectively.RESULTS:
The patients were predominantly female(11/12, 92%) and nonsmokers(12/12, 100%). Coughing (10/12, 83%), sputum(10/12, 83%) and hemoptysis(10/12, 83%) were the common symptoms and they had prolonged periods from the onset of symptoms to the diagnosis of their disease(median 6.5 years). Eleven (92%) patients had a previous history of being treated for pulmonary tuberculosis. The sputum specimens were acid-fast bacilli smear-positive in all patients. All patients were administered antituberculosis drugs. Six (50%) patients were treated with second-line antituberculosis drugs on account of persistent smear-positive sputum specimens. The chest radiographs showed that reticulonodular opacities(11/12, 92%) were the most common pattern of abnormality, followed by cavitary lesions(5/12, 42%). The computed tomography findings suggested bronchiolitis from the centrilobular nodules with a tree-in-bud appearances(9/10, 90%) and bronchiectasis (9/10, 90%) were the most common, followed by well-defined nodules smaller than 10-mm in diameter(7/10, 70%).CONCLUSIONS:
M. abscessus pulmonary disease should be recognized as a cause of chronic mycobacterial lung disease, and respiratory isolates should be assessed carefully.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sputum
/
Tuberculosis, Pulmonary
/
Bronchiectasis
/
Bronchiolitis
/
Radiography, Thoracic
/
Retrospective Studies
/
Cough
/
Diagnosis
/
Korea
/
Lung Diseases
Type of study:
Diagnostic study
/
Observational study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2003
Type:
Article
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