Prostaglandin F2alpha and Recurrences of Febrile Seizures / 대한소아신경학회지

ABSTRACT

PURPOSE: Intracerebroventricular injection of prostaglandin(PG) in the central nervous system is accompanied by a decrease in convulsions, a modulation of recurrences of seizures. Therefore, we observed the change of prostaglandin F2alpha(PGF2alpha) according to temperatures in the first febrile convulsions, and the relationship between the recurrence of febrile convulsions. METHODS: 93 patients with febrile convulsions recurrence could be studied for 42 months. All CSF samples were analyzed. During febrile convulsions, no anticonvulsant was used. We analyzed the recurrences of febrile convulsion according to PGF2alpha levels. RESULTS: The levels of PGF2alpha during 3 months recurrence group were 194.9+/-89.7 pg/mL, those during 4-6 months were 224.0+/-104.4 pg/mL, those during 7-9 months were 101.9+/-46.0 pg/mL, those during 10-12 months were 195.7+/-77.5 pg/mL, those during 13-18 months were 182.4+/-91.1 pg/mL, those during 19-24 months were 359.8+/-284.1 pg/mL, those during 25-36 months were 215.5+/-14.8 pg/mL and those during 37-42 months were 191.5+/-5.0 pg/mL. CONCLUSION: Elevated concentrations of PGF2alpha in febrile convulsions were found and not related to the increasing rate of fever. In the recurrent groups of febrile convulsions, there was no relationship between PGF2alpha levels and recurrences time of febrile convulsions except 7-9 months recurrence group. Although the exact mechanism of recurrence of febrile convulsion is unclear, we think that more consistent study of this recurrence is important to clarify the role of prostaglandin in the first febrile convulsion and the relationship to recurrences of febrile convulsions.