Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Young Children with Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System
Journal of Korean Medical Science
;
: 135-140, 2012.
Article
in English
| WPRIM
| ID: wpr-156443
ABSTRACT
The feasibility and effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) were evaluated in children younger than 3 yr of age with atypical teratoid/rhabdoid tumors (ATRT). Tandem HDCT/autoSCT was administered following six cycles of induction chemotherapy. Radiotherapy (RT) was administered if the tumor relapsed or progressed, otherwise, it was administered after 3 yr of age. Tumors relapsed or progressed during induction chemotherapy in 5 of 9 patients enrolled; 3 of these 5 received tandem HDCT/autoSCT as a salvage treatment. One patient died from sepsis during induction chemotherapy. The remaining 3 patients proceeded to tandem HDCT/autoSCT; however, 2 of these patients showed tumor relapse/progression after tandem HDCT/autoSCT. All 7 relapses/progressions occurred at primary sites even in patients with leptomeningeal seeding. Toxicities during tandem HDCT/autoSCT were manageable. A total of 5 patients were alive with a median follow-up of 20 (range 16-70) months from diagnosis. Four of 5 patients who received RT after relapse/progression are alive. The probability of overall survival at 3 yr from diagnosis was 53.3% +/- 17.3%. Our tandem HDCT/autoSCT is feasible; however, early administration of RT prior to tandem HDCT/autoSCT should be considered to improve the outcome after tandem HDCT/autoSCT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Transplantation, Autologous
/
Antineoplastic Combined Chemotherapy Protocols
/
Survival Rate
/
Prospective Studies
/
Follow-Up Studies
/
Carboplatin
/
Salvage Therapy
/
Central Nervous System Neoplasms
/
Thiotepa
Type of study:
Observational study
/
Prognostic study
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2012
Type:
Article
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