A Study of Antidepressant and Mood Stabilizer's Effect on Phase of Peripheral Circadian Rhythm in Rat Fibroblast / 대한정신약물학회지

ABSTRACT

OBJECTIVE: Circadian rhythm is cyclic variations in biological activity, which is crucial for physiology in mammals and alterations in circadian rhythm may be related to mood disorders. However, the effect of mood disorder medications on peripheral tissue is less understood. In this study, we investigated whether treatment with antidepressants, antipsychotics, and mood stabilizers in rat fibroblast influenced circadian rhythm. METHODS: Lithium, bupropion, risperidone, lamotrigine, and paroxetine were used on cultured NIH3T3, peripheral rat fibroblast and we observed the periodic oscillation and rhythmicity of Per2, Bmal1 mRNA for 48 hours. RESULTS: We found that lithium has a dose-dependent effect on phase change of circadian rhythm and buproipion has a tendency to dampen the amplitude. Risperidone, lamotrigine, and paroxetine had no influence on circadian rhythm in NIH3T3 cell. CONCLUSION: These results suggest that lithium treatment may have an effect on circadian rhythm lengthening in peripheral fibroblast tissue.