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Application of Iron Related Magnetic Resonance Imaging in the Neurological Disorders / 대한임상신경생리학회지
Korean Journal of Clinical Neurophysiology ; : 1-7, 2014.
Article in Korean | WPRIM | ID: wpr-156824
ABSTRACT
Iron is an important element for brain oxygen transport, myelination, DNA synthesis and neurotransmission. However, excessive iron can generate reactive oxygen species and contribute neurotoxicity. Although brain iron deposition is the natural process with normal aging, excessive iron accumulation is also observed in various neurological disorders such as neurodegeneration with brain iron accumulation, Parkinson's disease, Alzheimer's disease, multiple sclerosis, Friedreich ataxia, and others. Magnetic resonance image (MRI) is a useful method for detecting iron deposits in the brain. It can be a powerful tool for diagnosis and monitoring, while furthering our understanding of the role of iron in the pathophysiology of a disease. In this review, we will introduce the mechanism of iron toxicity and the basics of several iron-related MRI techniques. Also, we will summarize the previous results concerning the clinical application of such MR imagings in various neurological disorders.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxygen / Parkinson Disease / Brain / Aging / DNA / Friedreich Ataxia / Magnetic Resonance Imaging / Reactive Oxygen Species / Synaptic Transmission / Neurodegenerative Diseases Type of study: Diagnostic study Language: Korean Journal: Korean Journal of Clinical Neurophysiology Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxygen / Parkinson Disease / Brain / Aging / DNA / Friedreich Ataxia / Magnetic Resonance Imaging / Reactive Oxygen Species / Synaptic Transmission / Neurodegenerative Diseases Type of study: Diagnostic study Language: Korean Journal: Korean Journal of Clinical Neurophysiology Year: 2014 Type: Article