Hypotensive Effect of Guanabenz Acetate(Rexitene(R))in Essential Hypertension;A Clinical Study
Korean Circulation Journal
;
: 117-124, 1989.
Article
in Korean
| WPRIM
| ID: wpr-156934
ABSTRACT
To evaluate the hypertensive effect of guanbenz acetate, we performed a prospective clinical study for 10 weeks or more in 27 patients with essential hypertension(mean age 51, mean supine blood pressure 176/105mmHg). The daily dose of guanabenz acetate was 8-49 mg. The results were as follows; 1) After 2, 4, 6 and 8 weeks of treatment, average supine systolic and diastolic blood pressures reduced to 156/94, 150/94, 149/93 and 144/93mmHg respectively(all P<0.05). 2) Pulse rate decreased slightly from pre-treatment average of 75 beats per minute to 71 beats per minute at the end of the study(P<0.05). 3) Average body weight, serum levels of total cholesterol, AST, ALT, BUN, creatinine, sodium and potassium were not significantly changed from pre-treatment values. 4) A few side effects in order of frequency were dry mouth, dizziness, sedation, weakness, etc. We conclude that guanabenz acetate may be used as an effective first line antihypertensive agent in essential hypertension.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Potassium
/
Sodium
/
Blood Pressure
/
Body Weight
/
Cholesterol
/
Prospective Studies
/
Creatinine
/
Dizziness
/
Guanabenz
/
Heart Rate
Type of study:
Observational study
Limits:
Humans
Language:
Korean
Journal:
Korean Circulation Journal
Year:
1989
Type:
Article
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