Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
;
: 122-126, 2017.
Article
in Korean
| WPRIM
| ID: wpr-157025
ABSTRACT
Approximately 90% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are associated with Helicobacter pylori infection and 10% of gastric MALT lymphomas occur independent of H. pylori infection. The gene translocation t(11;18)(q21;q21) is frequently observed in cases presenting with H. pylori-negative gastric MALT lymphomas. H. pylori-negative gastric MALT lymphomas do not differ from H. pylori-positive gastric MALT lymphomas in terms of clinical features and endoscopic findings and show similar prognosis. H. pylori eradication therapy could be considered as first-line treatment for gastric MALT lymphomas regardless of their H. pylori infection status. In cases with H. pylori-negative gastric MALT lymphomas, the rate of response to eradication therapy varies from 0 to 83%. If gastric MALT lymphoma persists for more than a year, secondary treatment with radiotherapy, chemotherapy, and/or surgery should be considered. Of note, the comparative outcome is excellent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Radiotherapy
/
B-Lymphocytes
/
Helicobacter pylori
/
Helicobacter
/
Lymphoma, B-Cell, Marginal Zone
/
Drug Therapy
/
Lymphoid Tissue
/
Lymphoma
Type of study:
Prognostic study
Language:
Korean
Journal:
The Korean Journal of Helicobacter and Upper Gastrointestinal Research
Year:
2017
Type:
Article
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