Huntington's Disease Confirmed by Genetic and Pathological Study
Journal of the Korean Neurological Association
;
: 725-737, 1996.
Article
in Korean
| WPRIM
| ID: wpr-157068
ABSTRACT
Huntington's disease is an autosomal dominantly inherited neurodegenerative disease, which is characterized by choreic movement and progressive dementia. A definite diagnosis of Huntington's disease cannot be made by clinical informations alone. Pathologic or genetic studies are necessary to exclude other neurodegenerative diseases which may present with familial dementia, dystonia, and chorea. We report a 40 year-old male patient with Huntington's disease confirmed by pathologic and genetic studies. His daughter who had rigidity, dystonia, involuntary movement, and progressive cognitive decline had abnormal CAG trinucleotide repeat on the short arm of chromosome 4. These findings confirmed that the korean patient with Huntington's disease has same genetic abnormalities with the western and other oriental patients with Huntington's disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arm
/
Chromosomes, Human, Pair 4
/
Nuclear Family
/
Chorea
/
Huntington Disease
/
Trinucleotide Repeats
/
Neurodegenerative Diseases
/
Dyskinesias
/
Dementia
/
Diagnosis
Type of study:
Diagnostic study
Limits:
Adult
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
1996
Type:
Article
Similar
MEDLINE
...
LILACS
LIS