Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1?
Journal of the Korean Society of Coloproctology
;
: 237-240, 2011.
Article
in English
| WPRIM
| ID: wpr-157255
ABSTRACT
PURPOSE:
Many kinds of substances are produced on vascular endothelial activation. The aim of this study is to confirm an increase in Endothelin-1 (ET-1), the most potent vasoconstrictor, which is produced by endothelial activation, in patients with chronic anal fissure and to infer the relationship between ET-1 and anal fissure chronicity.METHODS:
The study groups are divided into three different groups with 30 subjects each. Group 1 is comprised of healthy volunteers, group 2 of chronic anal fissure patients, and Group 3 of patients with higher than 3rd degree hemorrhoids. Blood samples were taken to measure the ET-1 levels in subject's serum and to compare the results with those for the control groups.RESULTS:
Among the 90 subjects, 38 were male, and 52 were female. The average age was 36.8. The average ET-1 level marked 1.47 +/- 0.78 pg/mL for male subjects and 1.16 +/- 0.47 pg/mL for female subjects (P = 0.02). The average ET-1 level in the patient groups is as follow 1.21 +/- 0.44 pg/mL in group 1, 1.46 +/- 0.83 pg/mL in group 2, and 1.20 +/- 0.56 pg/mL in group 3 (P = 0.14).CONCLUSION:
Group 2, the chronic anal fissure patient group, showed a higher ET-1 level than groups 1 and 3, the control group and the hemorrhoid patient group, but this difference had no statistical significance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Endothelin-1
/
Endothelium
/
Fissure in Ano
/
Hemorrhoids
/
Ischemia
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of the Korean Society of Coloproctology
Year:
2011
Type:
Article
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