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Transarterial Chemoembolization Using Gelatin Sponges or Microspheres Plus Lipiodol-Doxorubicin versus Doxorubicin-Loaded Beads for the Treatment of Hepatocellular Carcinoma
Article in En | WPRIM | ID: wpr-157422
Responsible library: WPRO
ABSTRACT
OBJECTIVE: To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB). MATERIALS AND METHODS: A total of 158 patients with HCC received TACE from November 2010 to November 2011 were enrolled in this study, including 64 (40.5%) received TACE with lipiodol-doxorubicin and gelatin sponges (group A), 41 (25.9%) received TACE with lipiodol-doxorubicin and microspheres (group B), and 53 (33.5%) received TACE with doxorubicin-loaded DEB (group C). Tumor response and adverse events (AEs) were evaluated. RESULTS: No significant difference was found at baseline among the three groups. The doxorubicin dosage in group C was significantly (p < 0.001) higher compared to the dose used in groups A or B (median, 50 mg vs. 31 mg or 25 mg). Significantly (p < 0.001) more patients in group C achieved complete response compared to those in groups A or B (32.1% vs. 6.3% or 2.4%). Significantly (p < 0.001) less patients in group C had progressive disease compared to those in groups A or B (34.0% vs. 57.8% or 68.3%). Minor AEs were more common in groups A and B compared to group C, with rates of 54.7%, 34.1%, and 5.7%, respectively. CONCLUSION: In patients with HCC, TACE with DEB offers better safety and efficacy profiles compared to either TACE with gelatin sponges or TACE with microspheres.
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Full text: 1 Index: WPRIM Main subject: Drug Carriers / Doxorubicin / Abdominal Pain / Retrospective Studies / Follow-Up Studies / Chemoembolization, Therapeutic / Ethiodized Oil / Carcinoma, Hepatocellular / Disease-Free Survival / Kaplan-Meier Estimate Type of study: Observational_studies / Prognostic_studies Limits: Adult / Aged / Female / Humans / Male Language: En Journal: Korean Journal of Radiology Year: 2015 Type: Article
Full text: 1 Index: WPRIM Main subject: Drug Carriers / Doxorubicin / Abdominal Pain / Retrospective Studies / Follow-Up Studies / Chemoembolization, Therapeutic / Ethiodized Oil / Carcinoma, Hepatocellular / Disease-Free Survival / Kaplan-Meier Estimate Type of study: Observational_studies / Prognostic_studies Limits: Adult / Aged / Female / Humans / Male Language: En Journal: Korean Journal of Radiology Year: 2015 Type: Article