Cancer Stem Cells in Primary Liver Cancers: Pathological Concepts and Imaging Findings
Korean Journal of Radiology
;
: 50-68, 2015.
Article
in English
| WPRIM
| ID: wpr-157428
ABSTRACT
There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth. Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes. Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations. In this article, we reviewed the recent concepts of CSCs in the development of primary liver cancers, focusing on their pathological and radiological findings. Awareness of the pathological concepts and imaging findings of primary liver cancers with features of CSCs is critical for accurate diagnosis, prediction of outcome, and appropriate treatment options for patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Neoplastic Stem Cells
/
Bile Duct Neoplasms
/
Bile Ducts, Intrahepatic
/
Magnetic Resonance Imaging
/
Tomography, X-Ray Computed
/
Cholangiocarcinoma
/
Carcinoma, Hepatocellular
/
Liver Neoplasms
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Radiology
Year:
2015
Type:
Article
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