Comparison of Metabolic Characteristics of Metabolically Healthy but Obese (MHO) Middle-Aged Men According to Different Criteria / 가정의학회지
Korean Journal of Family Medicine
;
: 19-26, 2013.
Article
in English
| WPRIM
| ID: wpr-157645
ABSTRACT
BACKGROUND:
To compare the prevalence and metabolic characteristics of metabolically healthy but obese (MHO) individuals according to different criteria.METHODS:
We examined 186 MHO middle-aged men (age, 37.2 years; body mass index [BMI], 27.2 kg/m2). The following methods were used to determine MHO the National Cholesterol Education Program (NCEP) Adult Treatment Panel III criteria, 0-2 cardiometabolic abnormalities; the Wildman criteria, 0-1 cardiometabolic abnormalities; the Karelis criteria, 0-1 cardiometabolic abnormalities; the homeostasis model assessment [HOMA] criteria (lowest quartile of HOMA). After dividing the overall subjects into two age groups, we compared the prevalence and clinical characteristics between MHO and at-risk groups according to four different criteria.RESULTS:
The prevalence of MHO using the NCEP, Wildman, Kaleris, and HOMA criteria were 70.4%, 59.7%, 28.5%, and 24.2%, respectively. The agreement between the groups according to the NCEP and Wildman criteria was substantial (kappa = 0.8, P < 0.001). Among individuals 35 years or younger, and regardless of method, the MHO subjects had significantly lower weight, waist circumference, BMI, body fat percentage, insulin, HOMA, alanine aminotransferase, triglyceride (TG), and TG/high density lipoprotein cholesterol (HDL-C) ratio than the at-risk subjects (P < 0.05); However, among individuals older than 35 years old, and regardless of method, the MHO subjects had different insulin, HOMA, HDL-C, and TG/HDL-C levels than the at-risk subjects (P < 0.05).CONCLUSION:
The differences in metabolic profile between MHO and at-risk groups varied according to age. MHO prevalence varies considerably according to the criteria employed. Expert consensus is needed in order to define a standardized protocol for determining MHO.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Body Mass Index
/
Adipose Tissue
/
Cholesterol
/
Prevalence
/
Consensus
/
Alanine Transaminase
/
Waist Circumference
/
Metabolome
/
Homeostasis
/
Insulin
Type of study:
Practice guideline
/
Prevalence study
/
Prognostic study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Family Medicine
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS