Serotypes and antimicrobial susceptibility in clinical isolates of Haemophilus influenzae from Korean children in prevaccination era
Journal of Korean Medical Science
;
: 616-622, 2000.
Article
in English
| WPRIM
| ID: wpr-15769
ABSTRACT
Fifty-five strains of Haemophilus influenzae recovered at a children's hospital in Korea from 1992 through 1997, were analyzed for serotype and antibiotic resistance. Antimicrobial susceptibility was tested by broth dilution method. Among the 55 strains, 26 were from normally sterile body fluids, of which 17 were from the immunocompetent children. Spectrum in the immunocompetent included meningitis (47%), bacteremic pneumonia (18%), and bacteremia without focus (35%). Three (12%) of 26 invasive infections were caused by non-type b one type d and two type f. Nine of 29 non-sterile body fluid isolates belonged to one of encapsulted serotypes four a, two c, one of each of b, d and e. Thirty two (58%) strains were resistant to ampicillin, and all of which produced beta-lactamase. All of the strains were highly susceptible to amoxicillin/clavulanate, cefixime, cefuroxime, azithromycin and ciprofloxacin, while 1 (2%), 7 (13%), 4 (7%) and 4 (7%) strains were intermediate to cefprozil, cefaclor, loracarbef, and clarithromycin, respectively. The serotype distribution of H. influenzae in Korean children is similar to those in developed countries before the introduction of Hib conjugate vaccine, and ampicillin resistance rate is among the highest published to date.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Microbial Sensitivity Tests
/
Serotyping
/
Haemophilus influenzae
/
Haemophilus Vaccines
/
Haemophilus Infections
/
Korea
/
Anti-Bacterial Agents
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2000
Type:
Article
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