Identification of Anti-G in Pregnant Women with RhD Negative Blood: The First Case in Korea / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 304-310, 2017.
Article
in Korean
| WPRIM
| ID: wpr-158036
ABSTRACT
Anti-G positivity can be misinterpreted as the presence of anti-D or -C antigen in an antibody identification test, as this antibody is known to show agglutination to D or C antigen-positive red cells. Correct identification of anti-G is important in pregnant women, as prenatal care or the need for RhIG administration can vary between anti-D and -C versus anti-G cases. We recently encountered a D-negative case with suspected anti-D and -C, which was ruled out by adsorption and elution tests, and ultimately confirmed the presence of anti-G. The pregnant woman was a 33-year-old patient with cde Rh phenotype with a previous history of spontaneous abortion, followed by administration of RhIG. The spouse's Rh phenotype was CDe. Initial antibody identification test showed 2+ positivity to C (homozygotes and heterozygotes) and trace to 1+ positivity to D. Upon additional adsorption and elution with R0r (cDe/cde) and r'r (Cde/ cde) red cells, we identified the antibody present in the patient's serum as anti-G. The patient is currently under close follow-up monitoring for anti-G titer using antibody titer testing with both CDe and CcDEe red cells. Periodic fetal cerebral Doppler examination is being carried out without evidence of fetal distress.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Prenatal Care
/
Abortion, Spontaneous
/
Follow-Up Studies
/
Rho(D) Immune Globulin
/
Adsorption
/
Agglutination
/
Pregnant Women
/
Fetal Distress
/
Korea
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
2017
Type:
Article
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