N-Acetylcysteine Improves Pancreatic Microcirculation and Alleviates the Severity of Acute Necrotizing Pancreatitis
Gut and Liver
;
: 357-362, 2013.
Article
in English
| WPRIM
| ID: wpr-158228
ABSTRACT
BACKGROUND/AIMS:
To investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP).METHODS:
Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group. The ANP model was established by a retrograde injection of 3% sodium taurocholate into the pancreatic duct. The NAC-treated group received an intravenous infusion of NAC just 2 hours before and 30 minutes after the induction of ANP. The pancreatic microvascular perfusion was measured with laser Doppler flowmetry and pancreatic samples were collected for histological examination.RESULTS:
The microvascular perfusion in the NAC-treated group decreased slightly and exhibited a significant increase compared to the ANP group (p<0.01). A pathological examination revealed that edema and inflammatory infiltration decreased, and the hemorrhaging and necrosis of the pancreas were significantly reduced.CONCLUSIONS:
NAC could improve pancreatic microvascular perfusion and alleviate the severity of sodium taurocholate-induced ANP, possibly representing a new therapeutic approach to prevent the progression of ANP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreas
/
Pancreatic Ducts
/
Perfusion
/
Acetylcysteine
/
Sodium
/
Taurocholic Acid
/
Infusions, Intravenous
/
Atrial Natriuretic Factor
/
Laser-Doppler Flowmetry
/
Pancreatitis, Acute Necrotizing
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Gut and Liver
Year:
2013
Type:
Article
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