Risk Factors for Development of Biliary Stricture in Patients Presenting with Bile Leak after Cholecystectomy
Gut and Liver
;
: 352-356, 2013.
Article
in English
| WPRIM
| ID: wpr-158229
ABSTRACT
BACKGROUND/AIMS:
This study was aimed at determining the factors associated with the development of benign biliary stricture (BBS) in patients who had sustained a bile duct injury (BDI) at cholecystectomy and developed bile leaks.METHODS:
A retrospective analysis of 214 patients with BDI who were referred to our center between January 1989 and December 2009 was done.RESULTS:
One hundred fifty-three (71%) patients developed BBS (group I), and 61 (29%) were normal (group II). By univariate analysis, female gender (p=0.02), open cholecystectomy as the index operation (p=0.0001), delay in the referral from identification of injury (p=0.04), persistence of an external biliary fistula (EBF) beyond 4 weeks (p=0.0001), EBF output >400 mL (p=0.01), presence of jaundice (p=0.0001), raised serum total bilirubin level (p=0.0001), raised serum alkaline phosphatase level (p=0.0001), and complete BDI (p=0.0001) were associated with the development of BBS. Furthermore, open cholecystectomy as the index operation (p=0.04), delayed referral (p=0.02), persistent EBF (p=0.03), and complete BDI (p=0.001) were found to predict patient outcome in the multivariate analysis.CONCLUSIONS:
For the majority of patients with BDI, the risk of developing BBS could have been predicted at the initial presentation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Referral and Consultation
/
Bile
/
Bile Ducts
/
Bilirubin
/
Cholecystectomy
/
Retrospective Studies
/
Risk Factors
/
Biliary Fistula
/
Constriction, Pathologic
/
Alkaline Phosphatase
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
Gut and Liver
Year:
2013
Type:
Article
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