Apoptosis and Expression of bcl-2, p53, and Ki-67 in Mycosis Fungoides / 대한피부과학회지
Korean Journal of Dermatology
;
: 603-609, 1999.
Article
in Korean
| WPRIM
| ID: wpr-158389
ABSTRACT
BACKGROUND:
Mycosis fungoides(MF) is a form of cutaneous T cell lymphoma with clonal differentiation of helpr' T cell. It has a patch, plaque, and tumor stage. But pathogenetic factors controlling the development and progression of MF are still unclear. Apoptosis plays a major role in developmental biology and homeostasis. The bcl-2 oncogene prolongs ce11 life by inhibiting apoptosis. The mutant pS3 gene induces apoptosis indirectly. Ki-67 antigen is the cell proliferation marker. Recently, it has been shown that the relationships among them are important in the tumorigenesis of the various tumors.OBJECTIVE:
The aim of this study was to examine the expression of these genes and apoptotic rate and clarify the relationship among them in the development and progression of MF.METHODS:
The eighteen specimens from 8 patients with MF and 10 specimens from benign lymphocytic infiltrating diseases including 5 lichen planus, 3 lupus erythematosus, and 2 contact dermatitis were included. We performed immunoperoxidase staining(LSAB technique) using monoclonal antibodies including bc1-2, p~53, and Ki-67(MIB1). We used ApoptaqTM(Oncor) in situ labelling kit for detecting apoptotic cell.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Developmental Biology
/
Lymphoma, T-Cell, Cutaneous
/
Mycosis Fungoides
/
Apoptosis
/
Ki-67 Antigen
/
Cell Proliferation
/
Dermatitis, Contact
/
Carcinogenesis
/
Homeostasis
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
1999
Type:
Article
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