Comparison of Erythropoietic Effect between Epoetin-alpha and Darbepoetin-alpha in Hemodialysis Patients: A Randomized Crossover Study / 대한신장학회지
Korean Journal of Nephrology
;
: 450-455, 2009.
Article
in Korean
| WPRIM
| ID: wpr-158412
ABSTRACT
PURPOSE:
We aim to compare the erythropoietic effects of epoetin-alpha (EA, 4000 IU SC thrice a week) with those of darbepoetin-alpha (DA, 60ug IV weekly, conversion rate to EA=2001).METHODS:
Forty one stable hemodialysis patients were enrolled in this randomized crossover study. After a washout period of erythropoietin stimulating agents (ESA), the patients with hemoglobin (Hb) level of 11.0 g/dL, we stopped ESA. When Hb level decreased to 30% change in EA efficiency relative to DA efficiency.CONCLUSION:
There was no significant difference in erythropoietic parameters for both EA and DA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reticulocytes
/
Recombinant Proteins
/
Hemoglobins
/
Erythropoietin
/
Renal Dialysis
/
Cross-Over Studies
/
Epoetin Alfa
/
Darbepoetin alfa
/
Anemia
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2009
Type:
Article
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