The Factors Influencing Level of Advanced Oxidation Protein Products (AOPP) in Hemodialysis Patients / 대한신장학회지

ABSTRACT

PURPOSE: Advanced oxidation protein products (AOPP) has long been considered as a useful marker to estimate oxidative stress in the hemodialysis (HD) patients. However, it has not been clarified what clinical factors can affect the plasma level of AOPP in the HD patients. Based on these, We investigated the correlation between plasma AOPP level and clinical factor, known to be associated with oxidative stress, in the maintenance HD patients. METHODS: Two groups (50 of normal healthy persons and 105 of stable HD patients) were independently subjected in this study, and statistical correlation between plasma AOPP level and several clinical factors were analyzed. RESULTS: Plasma level of AOPP in the maintenance HD patients were higher than those in normal healthy group (52.11+/-16.08 micrometerol/L vs. 40.25+/-12.23 micrometerol/L, p<0.001). Plasma AOPP level of maintenance HD patients were significantly correlated with duration of hemodialysis, MDRD-GFR and daily urine volume. However, plasma level of AOPP in the maintenance HD patients were not affected by sex, diabetes, smoking, angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, and those were not correlated with age, CRP and serum ferritin. It was demonstrated by multiple regression analysis that daily urine volume was the most important clinical factor which could affect the plasma level of AOPP (beta=-0.255, p=0.017). CONCLUSION: These results suggest that maintenance of daily urine volume is likely to be critical to reduce oxidative stress in the maintenance HD patients.