Prognostic factors in neuroendocrine cervical carcinoma
Obstetrics & Gynecology Science
;
: 116-122, 2016.
Article
in English
| WPRIM
| ID: wpr-158473
ABSTRACT
OBJECTIVE:
To evaluate the clinical and pathologic factors associated with survival in patients with neuroendocrine cervical carcinoma (NECC).METHODS:
The records of 61 patients with NECC diagnosed between 2000 and 2014 at Seoul National University Hospital and the National Cancer Center were retrospectively reviewed. Kaplan-Meier and Cox regression methods were used for analyses.RESULTS:
Of the 61 patients, 67.2% were diagnosed at early stage (I to IIA) with a median age of 49 years. Of those, 78% underwent surgery and 75.6% received postoperative adjuvant treatment. For patients diagnosed at advanced stage, 60.0% received chemotherapy only and 25.0% received concurrent chemoradiation therapy. In the univariate analysis, advanced stage (77 vs. 40 months, P=0.013), tumor size ≥2 cm (133 vs. 47 months, P=0.002) and mixed tumor (101 vs. 34 months, P=0.004) were shown to be poor prognostic factors. In the multivariate analysis, tumor stage, tumor size and tumor homology were shown to be independent prognostic factors for overall survival. Of the total, 39.3% of the patients experienced recurrence, and 54.1% of the patients had metastasis. Of the patients diagnosed at early stage, 51.2% experienced recurrence.CONCLUSION:
Tumor stage, tumor size and tumor homology were found to be independent prognostic factors in patients with NECC. Even in patients diagnosed at early stage, recurrence and distant metastasis were frequently observed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Multivariate Analysis
/
Retrospective Studies
/
Carcinoma, Small Cell
/
Carcinoma, Neuroendocrine
/
Drug Therapy
/
Seoul
/
Neoplasm Metastasis
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Obstetrics & Gynecology Science
Year:
2016
Type:
Article
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