Esophageal Stricture Secondary to Candidiasis in a Child with Glycogen Storage Disease 1b / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
;
: 71-75, 2016.
Article
in English
| WPRIM
| ID: wpr-158489
ABSTRACT
Esophageal candidiasis is commonly seen in immunocompromised patients; however, candida esophagitis induced stricture is a very rare complication. We report the first case of esophageal stricture secondary to candidiasis in a glycogen storage disease (GSD) 1b child. The patient was diagnosed with GSD type 1b by liver biopsy. No mutation was found in the G6PC gene, but SLC37A4 gene sequencing revealed a compound heterozygous mutation (p.R28H and p.W107X, which was a novel mutation). The patient's absolute neutrophil count was continuously under 1,000/µL when he was over 6 years of age. He was admitted frequently for recurrent fever and infection, and frequently received intravenous antibiotics, antifungal agents. He complained of persistent dysphagia beginning at age 7 years. Esophageal stricture and multiple whitish patches were observed by endoscopy and endoscopic biopsy revealed numerous fungal hyphae consistent with candida esophagitis. He received esophageal balloon dilatation four times, and his symptoms improved.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biopsy
/
Candida
/
Candidiasis
/
Deglutition Disorders
/
Glycogen Storage Disease
/
Immunocompromised Host
/
Constriction, Pathologic
/
Hyphae
/
Dilatation
/
Endoscopy
Limits:
Child
/
Humans
Language:
English
Journal:
Pediatric Gastroenterology, Hepatology & Nutrition
Year:
2016
Type:
Article
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