Effect of rhPMP-2 coated implants on alveolar ridge augmentation in dogs / 대한치과보철학회지

ABSTRACT

PURPOSE: This study was aimed to evaluate the effect of rhPMP-2 coated implants on alveolar ridge augmentation in dogs. Material and METHODS: Six Beagle dogs were used in this study. Six 8.0 mm long anodized surface titanium implants were placed 5 mm into the mandibular alveolar ridge following 6 month of healing period after extraction. Each animal received three implants coated with rhBMP-2 and three uncoated control implants using the randomized split-mouth design. Radiographic examinations were undertaken i mmediately at implant placement (baseline), at weeks 4 and 8 after implant placement. The amount of bone augmentation was evaluated by measuring the distance from the uppermost point of the coverscrew to the marginal bone. Implant Stability Quotient (ISQ) values were measured i mmediately at implant placement and 8 weeks after implant placement. For the statistical analysis, Man-Whitney ranksum test and Wilcoxon signed rank test of SPSS 12.0 software were used (P = .05). RESULTS: The BMP group exhibited radiographic vertical bone augmentation about 0.6 +/- 0.7 mm at 8 weeks later while controls showed bone loss about 0.4 +/- 0.6 mm. There was significant difference among the rhBMP-2 group and controls in bone level change (P < .05). The ISQ values were significantly higher in the BMP-2 group than the control group at 8 weeks later (P < .05), while there was no significant difference at surgery. CONCLUSION: Within the limitation of this study, the rhBMP-2 coated on anodized implant could stimulate vertical alveolar bone augmentation, which may increase implant stability significantly on completely healed alveolar ridge.