A Case of Thrombotic Thrombocytopenic Purpura

ABSTRACT

A thrombotic thrombocytopenic purpura (TTP) is a disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, neurologic symptoms, fever, and impairment of renal function, which are thought to be due to endothelial cell injury, platelet activation, and subsequent formation of thrombi in the microcirculation. The most common neurologic symptoms are alteration of mental status, headache, coma, focal weakness, aphagia, dysarthria, seizure, and visual changes. Avoiding platelet transfusions, which can exacerbate microvascular thrombosis, is prudent. We experienced a case of TTP which was aggravated after platelet transfusion. We report that case with a literature review.