A Clinical Usefulness of Premedication with Hyoscine N-butyl Bromide in Colonoscopy / 대한소화기내시경학회지
Korean Journal of Gastrointestinal Endoscopy
;
: 10-15, 2010.
Article
in Korean
| WPRIM
| ID: wpr-158698
ABSTRACT
BACKGROUND/AIMS:
We conducted a prospective, randomized, double-blinded, placebo-controlled trial to investigate the effect of hyoscine-N-butyl bromide during colonoscopy.METHODS:
A total of 133 patients undergoing colonoscopy were randomized to receive either 20 mg of hyoscine-N-butyl bromide (n=70) or normal saline solution (n=63) via intramuscular injection as premedication.RESULTS:
The mean cecal intubation time and withdrawal time in the hyoscine-N-butyl bromide group were significantly shorter than those of the control group (5.26+/-2.78 min vs. 6.74+/-4.89 min; p=0.032, 5.42+/-1.54 min vs. 6.18+/-2.54 min; p=0.038, each). The spasm grade in the hyoscine-N-butyl bromide group was significantly lower than that of the control group (p<0.001). No significant differences were found in the polyp detection rate (15.7% vs. 28.6%; p=0.073) and adenoma detection rate (10.0% vs. 15.9%; p=0.311). Difficulty of colonoscopy for the endoscopists and nurses (p=0.853; p=0.732), the patient's comfort (p=0.891) and the patient's willingness to repeat colonoscopy (85.7% vs. 82.5%; p=0.932) were also similar in both groups.CONCLUSIONS:
Premedication with intramuscularly administered hyoscine-N-butyl bromide do not demonstrate any additional benefits except reducing the colonoscopy insertion time.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parasympatholytics
/
Polyps
/
Premedication
/
Scopolamine
/
Spasm
/
Sodium Chloride
/
Adenoma
/
Prospective Studies
/
Colonoscopy
/
Injections, Intramuscular
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Gastrointestinal Endoscopy
Year:
2010
Type:
Article
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