In Situ Follicular Lymphoma Developed after Hodgkin Lymphoma
Korean Journal of Pathology
;
: S53-S57, 2011.
Article
in English
| WPRIM
| ID: wpr-158726
ABSTRACT
In situ follicular lymphoma is a newly defined entity among the lymphoid neoplasms and is defined as architecturally normal-appearing lymph nodes and other lymphoid tissues that have one or more follicles that demonstrate bcl-2 overexpressing centrocytes and centroblasts, with or without a monomorphic cytologic appearance suggestive of follicular lymphoma. Here we present a case of in situ follicular lymphoma diagnosed during the follow-up after a complete response to the treatment of lymphocyte-rich classical Hodgkin's lymphoma. In our case, because only a few germinal centers contained bcl-2 overexpressing cells, we missed the diagnosis of in situ follicular lymphoma in the initial histological examination. We could establish the diagnosis only after performing bcl-2 immunostaining in the sequential biopsy. Therefore, we recommend that careful histological examination along with bcl-2 immunostaining is needed in patients with suspicious clinical findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Precancerous Conditions
/
Biopsy
/
Hodgkin Disease
/
Follow-Up Studies
/
Lymphoma, Follicular
/
Germinal Center
/
Lymph Nodes
/
Lymphoid Tissue
/
Lymphoma
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2011
Type:
Article
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