Efficacy of Venlafaxine Hydrochloride Extended Release for the Treatment of Perimenopausal Depressive Women with Vasomotor Symptoms: Open-Label Observation Study / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 186-191, 2014.
Article
in Korean
| WPRIM
| ID: wpr-15886
ABSTRACT
OBJECTIVE:
During the transition to menopause, various symptoms including vasomotor symptoms and depressed mood lead to low quality of life. We investigated the effect of low-dose venlafaxine hydrochloride extended release on depressed mood and vasomotor symptoms of perimenopausal women.METHODS:
33 perimenopausal women fulfilling Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria for a depressive episode were enrolled between January 2014 and May 2014. Subjects were prescribed 37.5 mg/day or 75 mg/day venlafaxine hydrochloride according to clinician's judgement, and the dosages were maintained for 8 weeks. Depressed mood and other psychological difficulties were evaluated by using Hamilton Rating Scale for Depression (HAMD), Hamilton Rating Scale for Anxiety (HAMA), Clinical Global Impression-Severity. Climacteric symptoms including vasomotor symptoms were evaluated by using Greene Climacteric Scale (GCS). For statistical analysis, paired t-test was used.RESULTS:
Significant decreases in HAMD, HAMA, GCS scores were observed after 2 weeks of treatment and the trends continued until the end of the study. The scores of HAMD significantly decreased, 28 of them reached remission (HAMD < or =7). The scores on vasomotor symptoms of GCS after 8 week treatment significantly decreased compared to baseline (13.1+/-5.0, p<0.01).CONCLUSION:
These results suggest that venlafaxine hydrochloride is effective and tolerable treatment option for vasomotor symptoms and depressed mood in perimenopausal women. To validate our results, furthur studies with double-blind, placebo controlled will be needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Quality of Life
/
Climacteric
/
Menopause
/
Diagnostic and Statistical Manual of Mental Disorders
/
Depression
/
Venlafaxine Hydrochloride
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Practice guideline
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2014
Type:
Article
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