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The Changes of Serologic Markers in Pneumoconiosis of Coal Workers / 결핵
Tuberculosis and Respiratory Diseases ; : 615-623, 2001.
Article in Korean | WPRIM | ID: wpr-158904
ABSTRACT

BACKGROUND:

Pneumoconiosis is a parenchymal lung disease that results from the accumulation of coal dust in the lungs and the consequent tissue reaction. To evaluate the role of various personal factors in pneumoconosis and the significance of some serologic markers for assessing the disease activity related to pneumoconiosis, the Rheumatoid Factor(RF), α1-AT, C-Reactive Protein(CRT), ceruloplasmin and fibrinogen levels were measured.

METHOD:

All the patients were males, 45-76 years old, and the mean duration of coal dust exposure was 23.2 years. 51 patients were classified as having Simple Pneumoconiosis (SP), 59 had Progressive Massive Fibrosis (PMF). Fifty eight men with ages ranging from 26-70 years wer used as normal controls. The serum RF and CRT were titrated using an Autochemistry analyzer (HITACHI 7150 Japan) and the α1-AT and ceruloplasmin levels were measured using a Nephelometer (Behring Nephelometer Germany) and the fibrinogen levels were estimated by using and Autoanalyzer for hematologic coagulation.

RESULT:

There was a higher RF level in the SP, and PMF groups than in the control groups but there was no statistical difference. The CRP, α1-AT, and ceruloplasmin levels were also higher in the SP, and PMF groups. However, the fibrinogen concentration was within the normal ranges in both the SP and PMF groups.

CONCLUSION:

The CWP (Ed note Define CWP) patients had significantly higher CRP, α1-AT, and ceruloplasmin levels compared to the control group. It is believed that these serologic changes could be used as a marker of the disease activity.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumoconiosis / Reference Values / Rheumatoid Factor / Fibrosis / C-Reactive Protein / Ceruloplasmin / Fibrinogen / Coal / Dust / Lung Limits: Humans / Male Language: Korean Journal: Tuberculosis and Respiratory Diseases Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumoconiosis / Reference Values / Rheumatoid Factor / Fibrosis / C-Reactive Protein / Ceruloplasmin / Fibrinogen / Coal / Dust / Lung Limits: Humans / Male Language: Korean Journal: Tuberculosis and Respiratory Diseases Year: 2001 Type: Article