The Role of AMPA Receptors in Synaptic Plasticity by Drugs of Abuse / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 149-154, 2014.
Article
in Korean
| WPRIM
| ID: wpr-15891
ABSTRACT
Dopamine has long time considered as the main player in drug addiction. However, growing body of literature strongly supports a role for glutamate in addiction. 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors, one of the ionotropic glutamate receptors, are known to be involved in different forms of synaptic plasticity, and behaviors such as learning and memory. As drug addiction is a chronic brain disease with characteristics of craving and relapse, it is often considered as a maladapted form of drug-induced long-term memory. Experimental evidence strongly indicates that AMPA receptor has an important role in the development of drug addiction. Studies with animal models of drug addiction, such as behavioral sensitization and drug self-administration, demonstrate that AMPA receptor-mediated synaptic plasticity may underlie the neuronal mechanisms for such important characteristics of addiction as drug craving.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plastics
/
Recurrence
/
Brain Diseases
/
Dopamine
/
Illicit Drugs
/
Receptors, AMPA
/
Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
/
Glutamic Acid
/
Substance-Related Disorders
/
Models, Animal
Type of study:
Prognostic study
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2014
Type:
Article
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