Effect of Botulinum Toxin Type A on Morphology of Salivary Glands in Patients with Cerebral Palsy
Annals of Rehabilitation Medicine
;
: 636-640, 2011.
Article
in English
| WPRIM
| ID: wpr-159266
ABSTRACT
OBJECTIVE:
To investigate the effect of botulinum toxin type A (BTXA) on drooling and the morphologic change of the salivary gland in patients with cerebral palsy.METHOD:
Eight cerebral palsy patients suffering from severe drooling participated in this study. BTXA was injected into both submandibular and parotid glands under intravenous sedation and with ultrasound guidance (1 unit/gland/kg maximum 100 units) in an outpatient or inpatient procedure. The severity of drooling was measured before injection and 3 weeks after injection using the Teacher Drooling Scale, the Drooling Score-severity, frequency and the Visual Analog Scale. To investigate the morphologic change of the salivary glands, the size of salivary glands were measured before injection and 3 weeks after injection using computed tomography of the neck. The measurement values were analyzed by Wilcoxon signed rank test.RESULTS:
Statistically significant improvements were shown in all three parameters for assessing the severity of drooling after BTXA injections (p<0.05). Size of the salivary glands were significantly decreased at 3 weeks after BTXA injection (p<0.05).CONCLUSION:
Salivary gland injection with BTXA could be a useful treatment method to reduce drooling in patients with cerebral palsy and decreased size of salivary glands may partially explain the mechanism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Outpatients
/
Parotid Gland
/
Salivary Glands
/
Sialorrhea
/
Stress, Psychological
/
Botulinum Toxins
/
Cerebral Palsy
/
Botulinum Toxins, Type A
/
Inpatients
/
Neck
Type of study:
Practice guideline
Limits:
Humans
Language:
English
Journal:
Annals of Rehabilitation Medicine
Year:
2011
Type:
Article
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