The Effects of Minoxidil Versus Mitomycin C on the Filteing Surgery for Glaucoma in Rabbits
Journal of the Korean Ophthalmological Society
;
: 666-673, 1997.
Article
in Korean
| WPRIM
| ID: wpr-159448
ABSTRACT
We compared the effect of topical minoxidil after filtering surgery with that of mitomycin C (MMC) application in rabbits. Fourty-nine eyes were divided into the minoxidil-treated eyes, MMC_treated eyes and control eyes. Intraocular pressure (IOP) in minoxidil-treated eyes and MMC-soaked eyes were significantly lower than that of the control eyes at postoperative 1 and 3 days. MMC-soaked eyes had lower IOPs than the minoxidil-treated and control eyes, but IOPs in the minoxidil- and control eyes were similar at days 5 to 21. IOP survival in the MMC-treated eyes was significantly longer than in both the minoxidil-treated and control eyes. These results suggest that topical minoxidil can cause reduction of IOP at the early postoperative period. Howver, the IOP lowering effect of Minoxidil did not last as long as that of MMC soaking. Further study is necessary to enhance the efect of topical minoxidil including its method of application and optimal concentration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
Glaucoma
/
Mitomycin
/
Filtering Surgery
/
Intraocular Pressure
/
Minoxidil
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
1997
Type:
Article
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