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Outcomes after bleomycin, etoposide and cisplatin combination chemotherapy in patients with ovarian yolk sac tumor / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology ; : 1007-1013, 2010.
Article in Korean | WPRIM | ID: wpr-159536
ABSTRACT

OBJECTIVE:

The aim of this study was to evaluate the oncologic and reproductive outcomes of patients with ovarian yolk sac tumor after bleomycin, etoposide, cisplatin (BEP) chemotherapy following surgery.

METHODS:

Of 145 patients with histologically confirmed malignant ovarian germ cell tumor, 43 had yolk sac tumor and received BEP chemotherapy after surgery. A retrospective analysis of these patients was performed.

RESULTS:

The mean age of 43 patients was 24.8 years (range, 7 to 59 years). Thirty eight patients were nulliparous. Of 179 BEP chemotherapy cycles, grade 1~2 hematologic and non-hematologic adverse events occurred in 46 cycles in 21 patients. Thirty nine patients showed complete remission, 1 patient showed partial remission, and 3 patient had progressive disease during BEP chemotherapy. After median follow-up time of 57 months (range, 3 to 153 months), 5 patients had recurrent disease and three of them died of disease. The 5-year recurrence free survival rate and overall survival rate were 86% and 94%, respectively. After chemotherapy, all but one premenarchal patients had normal menstruation. Of them 5 patients tried to conceive and 3 of them succeeded in pregnancy.

CONCLUSION:

BEP chemotherapy was very safe and effective in patients with ovarian yolk sac tumor. Survival outcomes are excellent and reproductive outcomes are promising after BEP chemotherapy.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Yolk Sac / Bleomycin / Survival Rate / Retrospective Studies / Follow-Up Studies / Cisplatin / Endodermal Sinus Tumor / Neoplasms, Germ Cell and Embryonal / Drug Therapy, Combination Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Yolk Sac / Bleomycin / Survival Rate / Retrospective Studies / Follow-Up Studies / Cisplatin / Endodermal Sinus Tumor / Neoplasms, Germ Cell and Embryonal / Drug Therapy, Combination Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 2010 Type: Article