Serum Interleukin-8 Levels in Leprosy Patients
Annals of Dermatology
;
: 1-4, 1999.
Article
in English
| WPRIM
| ID: wpr-15965
ABSTRACT
BACKGROUND:
Interleukin(IL)-8 is a potent chemotactic factor for neutrophils which was induced by tumor necrosis factor-a and IL-1. Serum IL-8 level was known to be associated with the poor prognosis of tuberculosis and IL-8 mRNA was increased in the tissue of erythema nodosum leprosum.OBJECTIVE:
Our purpose was to investigate whether the serum IL-8 levels of leprosy patients are different from those of controls and whether the severity of the leprosy is associated with the serum IL-8 level.METHODS:
Twenty eight patients with leprosy and fourteen healthy adults were used in this study. Serum IL-8 levels were detected by enzyme immunoassay.RESULTS:
There were no statistically significant differences in the serum IL-8 levels between the twenty eight leprosy patients and the fourteen healthy control serums (29.99±53.14 vs 2.52±7.53) nor was the detection rate between the groups (9/28 vs 1/14) significant. There were also no statistically significant differences between the serum IL-8 concentrations of the patients with high bacterial indexes and the patients with low bacterial indexes (30.22±63.64 vs 29.73±41.14).CONCLUSION:
Serum levels and the detection rate of IL-8 in the leprosy patients were not different from the control group and the severity of the disease was not associated with the IL-8 levels.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Tuberculosis
/
RNA, Messenger
/
Interleukin-8
/
Immunoenzyme Techniques
/
Interleukin-1
/
Erythema Nodosum
/
Leprosy
/
Necrosis
/
Neutrophils
Type of study:
Prognostic study
Limits:
Adult
/
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
1999
Type:
Article
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