Geriatric clinical pharmacology and clinical trials in the elderly
Translational and Clinical Pharmacology
;
: 64-69, 2014.
Article
in English
| WPRIM
| ID: wpr-159744
ABSTRACT
The aging process is linked to changes in the physiological function of organs and changes in body composition that alter the pharmacokinetics of drugs and pharmacodynamic responses. Comorbidity and polypharmacy in the elderly decreases tolerability of drugs, leading to greater vulnerability to adverse drug reactions than that observed in younger adults. In geriatric pharmacotherapy, the general recommendation is dose reduction and slow titration, which is based on pharmacokinetic considerations and concern for adverse drug reactions, rather than clinical trial data. Older patients are under-represented in clinical trials. In the absence of evidence, extrapolation of risk-benefit ratios from younger adults to geriatric populations is not necessarily valid. Sound evidence through prospective clinical trials is essential, and geriatric societies, governments, and patient advocacy groups should collaborate to promote the inclusion of older people in clinical trials. It is believed that all involved in clinical trials have both an obligation and an opportunity to eliminate age discrimination in clinical trial practice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Patient Advocacy
/
Pharmacology, Clinical
/
Body Composition
/
Aging
/
Pharmacokinetics
/
Comorbidity
/
Polypharmacy
/
Drug Therapy
/
Drug-Related Side Effects and Adverse Reactions
/
Ageism
Type of study:
Practice guideline
Limits:
Adult
/
Aged
/
Humans
Language:
English
Journal:
Translational and Clinical Pharmacology
Year:
2014
Type:
Article
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