Immunohistochemical study on the expression of calcium binding proteins (calbindin-D28k, calretinin, and parvalbumin) in the cerebral cortex and in the hippocampal region of nNOS knock-out(-/-) mice / 대한해부학회지
Anatomy & Cell Biology
;
: 106-115, 2011.
Article
in English
| WPRIM
| ID: wpr-159930
ABSTRACT
Nitric oxide (NO) modulates the activities of various channels and receptors to participate in the regulation of neuronal intracellular Ca2+ levels. Ca2+ binding protein (CaBP) expression may also be altered by NO. Accordingly, we examined expression changes in calbindin-D28k, calretinin, and parvalbumin in the cerebral cortex and hippocampal region of neuronal NO synthase knockout(-/-) (nNOS-/-) mice using immunohistochemistry. For the first time, we demonstrate that the expression of CaBPs is specifically altered in the cerebral cortex and hippocampal region of nNOS-/- mice and that their expression changed according to neuronal type. As changes in CaBP expression can influence temporal and spatial intracellular Ca2+ levels, it appears that NO may be involved in various functions, such as modulating neuronal Ca2+ homeostasis, regulating synaptic transmission, and neuroprotection, by influencing the expression of CaBPs. Therefore, these results suggest another mechanism by which NO participates in the regulation of neuronal Ca2+ homeostasis. However, the exact mechanisms of this regulation and its functional significance require further investigation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
S100 Calcium Binding Protein G
/
Calcium-Binding Proteins
/
Immunohistochemistry
/
Carrier Proteins
/
Cerebral Cortex
/
Calcium
/
Synaptic Transmission
/
Nitric Oxide Synthase
/
Homeostasis
/
Neurons
Limits:
Animals
Language:
English
Journal:
Anatomy & Cell Biology
Year:
2011
Type:
Article
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