Preemptive Analgesic Effect of Magnesium Sulfate on Postoperative Pain after Hysterectomy / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 447-452, 1999.
Article
in Korean
| WPRIM
| ID: wpr-160254
ABSTRACT
BACKGROUND:
Recent studies suggest that preoperative block of the N-Methyl-D-Aspartate (NMDA) receptor with NMDA antagonists may reduce postoperative pain. We infused magnesium sulfate, anatural NMDA receptor antagonist, preoperatively to evaluate the preemptive analgesic effect of magnesium.METHODS:
Sixty healthy patients who underwent total abdominal hysterectomy under general sthesia were randomly divided into three groups. Group 1 was the control group, while Groups 2 and 3 received intravenous magnesium (Group 2 0.1 mg/kg bolus, 0.015 mg/kg/hr for 6hr, Group 3 0.2 mg/kg bolus, 0.03 mg/kg/hr for 6hr). Postoperative pain scorers (Visual Analog Scale VAS and Prince Henry Score PHS) and the amount of analgesic consumption were evaluated at 6, 24, 48 and 72 hours by a double blind manner.RESULTS:
The patients in Group 3 had lower pain scores at 6 and 24 hours compared to those in Group 1, but there were no significant differences in PHS and cumulative amounts of analgesic consumption among the three groups.CONCLUSIONS:
The preoperative administration of intravenous magnesium reduced postoperative pain scores. However, further study is needed before its clinical use for postoperative analgesic purposes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain, Postoperative
/
N-Methylaspartate
/
Hydrogen-Ion Concentration
/
Hysterectomy
/
Magnesium
/
Magnesium Sulfate
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1999
Type:
Article
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