A Comparison of the Effects of Ondansetron and Granisetron on the Prevention of Postoperative Nausea and Vomiting after Gynecologic Surgery / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 431-435, 1999.
Article
in Korean
| WPRIM
| ID: wpr-160257
ABSTRACT
BACKGROUND:
The purpose of this study was to compare the effects of ondansetron and granisetron on the prevention of postoperative nausea and vomiting (PONV) in gynecologic patients.METHODS:
In a randomized placebo-controlled study, 200 gynecologic patients were divided into 5 groups. Each patient received one of 5 medications placebo (saline 3 ml), ondansetron 4 mg (O4), ondansetron 8 mg (O8), granisetron 1.5 mg (G1.5) and granisetron 3 mg (G3). They were administered intravenously immediately before the induction of anesthesia. A standardized inhalation anesthesia and a postoperative intravenous patient-controlled analgesia were applied. Twenty four hours after anesthesia, the incidence and severity of PONV and other adverse effects were assessed.RESULTS:
The incidence of PONV was 88%, 83%, 75%, 70% and 60% in the placebo, O4, O8, G1.5 and G3 groups, respectively, which showed significantly lower value in the G3 group than in the placebo and O4 groups (P< 0.05). The severity of PONV was also significantly lower in the G3 group than in the placebo group (P < 0.05).CONCLUSIONS:
In this study, granisetron 3 mg showed a better prophylactic effect in the mitigation of PONV in gynecologic patients then a placebo or ondansetron 4 mg.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Gynecologic Surgical Procedures
/
Incidence
/
Analgesia, Patient-Controlled
/
Ondansetron
/
Granisetron
/
Postoperative Nausea and Vomiting
/
Anesthesia
/
Anesthesia, Inhalation
Type of study:
Controlled clinical trial
/
Incidence study
/
Prognostic study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1999
Type:
Article
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