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The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion / 대한불임학회지
Korean Journal of Fertility and Sterility ; : 247-2001.
Article in Korean | WPRIM | ID: wpr-160310
ABSTRACT

OBJECTIVE:

To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. MATERIAL AND

METHOD:

The blood samples of patients with recurrent spontaneous abortion were tested by PCR-RFLP method.

RESULTS:

Of 51 cases of study group, 14 (27.5%) were normal, 25 (49.0%) were heterozygosity, and 12 (23.5%) were homozygosity. Of 58 cases of control group, 20 (34.5%) were normal, 30 (51.7%) were heterozygosity, and 8 (13.8%) were homozygosity. But the difference between two groups was not significant (p=0.190).

CONCLUSION:

Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the study for MTHFR mutation should be included in the workup of recurrent spontaneous abortion.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Abortion, Spontaneous / Hyperhomocysteinemia / Methylenetetrahydrofolate Reductase (NADPH2) Limits: Female / Humans / Pregnancy Language: Korean Journal: Korean Journal of Fertility and Sterility Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Abortion, Spontaneous / Hyperhomocysteinemia / Methylenetetrahydrofolate Reductase (NADPH2) Limits: Female / Humans / Pregnancy Language: Korean Journal: Korean Journal of Fertility and Sterility Year: 2001 Type: Article