The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion / 대한불임학회지
Korean Journal of Fertility and Sterility
;
: 247-2001.
Article
in Korean
| WPRIM
| ID: wpr-160310
ABSTRACT
OBJECTIVE:
To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. MATERIAL ANDMETHOD:
The blood samples of patients with recurrent spontaneous abortion were tested by PCR-RFLP method.RESULTS:
Of 51 cases of study group, 14 (27.5%) were normal, 25 (49.0%) were heterozygosity, and 12 (23.5%) were homozygosity. Of 58 cases of control group, 20 (34.5%) were normal, 30 (51.7%) were heterozygosity, and 8 (13.8%) were homozygosity. But the difference between two groups was not significant (p=0.190).CONCLUSION:
Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the study for MTHFR mutation should be included in the workup of recurrent spontaneous abortion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Abortion, Spontaneous
/
Hyperhomocysteinemia
/
Methylenetetrahydrofolate Reductase (NADPH2)
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Fertility and Sterility
Year:
2001
Type:
Article
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