Interleukin-32 Gamma as a New Face in Inflammatory Bone Diseases
Journal of Rheumatic Diseases
;
: 14-20, 2017.
Article
in English
| WPRIM
| ID: wpr-160555
ABSTRACT
Interleukin-32 (IL-32), a recently identified pro-inflammatory cytokine, is involved in the pathogenesis and progression of infections, cancer, chronic inflammation, and autoimmune disease. IL-32γ is the most active isoform in cell death and cell activation among nine distinct isoforms of IL-32. IL-32γ potentiates both osteogenic and osteoclastogenic capacities, and is critical in the coupling of bone resorption and bone formation for maintenance of bone homeostasis. IL-32γ is strongly associated with inflammatory bone disorders such as rheumatoid arthritis, ankylosing spondylitis, and osteoporosis. In this review, we summarize current research on the role of IL-32γ in inflammatory bone disorders, highlighting this cytokine as a novel target for prognostic marker and control of these diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Osteoporosis
/
Arthritis, Rheumatoid
/
Autoimmune Diseases
/
Spondylitis, Ankylosing
/
Bone Diseases
/
Bone Resorption
/
Cell Death
/
Protein Isoforms
/
Homeostasis
Language:
English
Journal:
Journal of Rheumatic Diseases
Year:
2017
Type:
Article
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