Deep Venous Thrombosis in the Lower Extremity: Catheter-Directed Thrombolysis
Journal of the Korean Radiological Society
;
: 291-297, 2000.
Article
in Korean
| WPRIM
| ID: wpr-16075
ABSTRACT
PURPOSE:
To evaluate the efficacy of catheter-directed thrombolysis in treating symptomatic deep venous thrombosis (DVT) in lower limbs. MATERIALS ANDMETHODS:
Twenty-six consecutive patients (16 male and 10 female; mean age, 55 years) with lower extremity DVT underwent thrombolytic therapy. The duration of symptoms was 1 -90 (mean, 17) days 20 days or less in 16 cases (acute DVT) and less than 20 days in ten (chronic DVT). Catheter-directed infusions of urokinase were administered via ipsilateral popliteal veins, and angioplasty or stent placement was performed after the thrombolytic procedure. Oral medication of warfarin continued for six months, and for the evaluation of venous patency, follow-up ultrasonography was performed. The total dose of infused urokinase was 1,750,000 -10,000,000 (mean 4, 84,000) IU, and the total procedural time was 25 -115 (mean, 64) hours.RESULTS:
Lysis was complete in 16 cases (62%, all acute DVT), partial in five (19%, chronic DVT), and failed in five (19%, chronic DVT). Eight patients with venous stenosis and two with occlusion were treated by means of angioplasty (n=4) or Wallstent placement (n=6). Minor bleeding occurred in six cases and major complications in two (one of pulmonary embolism, and one of multiorgan failure).CONCLUSION:
Catheter-directed thrombolysis with urokinase is effective for the treatment of DVT in lower limbs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Popliteal Vein
/
Pulmonary Embolism
/
Warfarin
/
Urokinase-Type Plasminogen Activator
/
Stents
/
Thrombolytic Therapy
/
Follow-Up Studies
/
Ultrasonography
/
Angioplasty
/
Constriction, Pathologic
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Radiological Society
Year:
2000
Type:
Article
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