Emergence and Spread of OXA-48-Like Carbapenemase-Producing Enterobacteriaceae / 병원감염관리
Korean Journal of Nosocomial Infection Control
;
: 7-18, 2015.
Article
in Korean
| WPRIM
| ID: wpr-160773
ABSTRACT
Since 2001, ten more OXA-48 variants have been identified. Shewanella spp. has been thought to be the original host for OXA-48-like enzymes. These enzymes strongly hydrolyze penicillins and weakly hydrolyze carbapenems, with very weak activity against broad-spectrum cephalosporins. The OXA-48-like genes are always plasmid-borne and have been located in insertion sequences. OXA-48-like carbapenemases have been identified mainly from Turkey, North African countries, the Middle East, and India. Furthermore, the emergence and outbreak of OXA-48-like producers in Korea have been reported recently. Because some OXA-48-like-producing Enterobacteriaceae isolates do not exhibit resistance to broad-spectrum cephalosporins and only decreased susceptibility to carbapenems, their detection can be difficult. Adequate screening and detection methods are required to prevent and control the dissemination of OXA-48-like-producing Enterobacteriaceae.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penicillins
/
Turkey
/
Carbapenems
/
Cephalosporins
/
Mass Screening
/
Shewanella
/
Enterobacteriaceae
/
India
/
Korea
/
Middle East
Type of study:
Screening study
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Nosocomial Infection Control
Year:
2015
Type:
Article
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