Micrometastasis of Sentinel Lymph Nodes in Gastric Cancer
Journal of the Korean Surgical Society
;
: 188-191, 2004.
Article
in Korean
| WPRIM
| ID: wpr-161372
ABSTRACT
PURPOSE:
A lymph node metastasis is one of most important prognostic factors of a malignancy. There is a growing interest in the role of the sentinel node (SN) in the detection of lymph node metastasis. However, the high false negative rate of a sentinel lymph node biopsy limits its utility. The aim of this study is to evaluate a micrometastasis of a gastric cancer to the histologically negative sentinel lymph nodes using the usual stains.METHODS:
The SN in 44 out of 57 patients revealed no lymph node metastasis with usual hematoxylin and eosin (H&E) staining. Those nodes were embedded in paraffin and 4-micrometer-thick sections underwent, H&E staining, and cytokeratin immunohisto-chemical (IHC) staining between March 2002 and December 2002.RESULTS:
Micrometastases were detected in 3 of the 44 patients without a SN metastasis. All micrometastases were detected in the patients who had metastases to the non-SN without a SN metastasis (3 of 5, 60%). Micrometastases to the SN were significantly frequent in those patients with a metastasis to the non-SN than those without a metastasis (P<0.001). From the detection of micrometastases, the sensitivity and false-negative rate of a sentinel lymph node biopsy ranged from 72.2% (13/18) to 88.9% (16/18), and from 12.8% (5/39) to 4.9% (2/41), respectively.CONCLUSION:
3 cases of micrometastasis of the SN without a metastasis were detected, and this increased the sensitivity and decreased the false negative rate of a SN biopsy. Micrometastases of the SNs were detected only in patients with a skip metastasis of the lymph nodes in this study.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraffin
/
Stomach Neoplasms
/
Biopsy
/
Eosine Yellowish-(YS)
/
Sentinel Lymph Node Biopsy
/
Coloring Agents
/
Neoplasm Micrometastasis
/
Hematoxylin
/
Keratins
/
Lymph Nodes
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Surgical Society
Year:
2004
Type:
Article
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