The graft- versus host disease due to blood transfussion: report of a case received blood transfussion in the Ho Chi Minh center for hematogy and blood transfusion

ABSTRACT

A 33 years old female with acute myeloid leukemia was treated with induction chemotherapy of 7-3-5 protocol (Cytarabine, Daunorubicine, Etoposide). On day 15 of chemotherapy; 15 days from the first blood transfusion and 1 day from the last, she developed high-grade fever, general erythroderma, diarrhea, hyperbilirubinemia and evaluation of liver enzymes. A diagnosis of TA- GVHD was suspected. The patients had no response to any therapy and expired 5 days later. TA-GVHD is uncommon complication; there is no effective therapy and high mortality. Since TA- GVHD can be prevented by irradiating blood products with 2,500- 3,500 rads, patients at high risk should receive irradiated blood products only.