New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development
Experimental & Molecular Medicine
;
: e83-2014.
Article
in English
| WPRIM
| ID: wpr-161402
ABSTRACT
To achieve immune homeostasis in such a harsh environment as the intestinal mucosa, both active and quiescent immunity operate simultaneously. Disruption of gut immune homeostasis leads to the development of intestinal immune diseases such as colitis and food allergies. Among various intestinal innate immune cells, mast cells (MCs) play critical roles in protective immunity against pathogenic microorganisms, especially at mucosal sites. This suggests the potential for a novel MC-targeting type of vaccine adjuvant. Dysregulated activation of MCs also results in inflammatory responses in mucosal compartments. The regulation of this yin and yang function of MCs remains to be elucidated. In this review, we focus on the roles of mucosal MCs in the regulation of intestinal allergic reaction, inflammation and their potential as a new target for the development of mucosal adjuvants.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Adjuvants, Immunologic
/
Hypersensitivity
/
Inflammation
/
Intestinal Mucosa
/
Mast Cells
Limits:
Animals
/
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2014
Type:
Article
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