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Mucosal dendritic cells shape mucosal immunity
Experimental & Molecular Medicine ; : e84-2014.
Article in English | WPRIM | ID: wpr-161403
ABSTRACT
Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal tissues, DCs act as surveillance systems to sense infection and also function as professional antigen-presenting cells that stimulate the differentiation of naive T and B cells. On the basis of their molecular expression, DCs can be divided into several subsets with unique functions. In this review, we focus on intestinal DC subsets and their function in bridging the innate signaling and adaptive immune systems to maintain the homeostasis of the intestinal immune environment. We also review the current strategies for manipulating mucosal DCs for the development of efficient mucosal vaccines to protect against infectious diseases.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Dendritic Cells / T-Lymphocytes, Helper-Inducer / Immunity, Mucosal / Intestinal Mucosa Limits: Animals / Humans Language: English Journal: Experimental & Molecular Medicine Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Dendritic Cells / T-Lymphocytes, Helper-Inducer / Immunity, Mucosal / Intestinal Mucosa Limits: Animals / Humans Language: English Journal: Experimental & Molecular Medicine Year: 2014 Type: Article