Effects of IL-7 on human lymphocytes
Journal of Korean Medical Science
;
: 93-98, 1993.
Article
in English
| WPRIM
| ID: wpr-161580
ABSTRACT
Interleukin-7 (IL-7) is known as a growth factor for pre B-cell and mature T-cells in human. But in leukemic cells, IL-7 effect is variously reported. To investigate the effect of IL-7 on the cells of childhood acute leukemia we used 3H-Thymidine assay. Twelve Acute lymphoblastic leukemia (ALL), seven T-ALL and three Acute myelogenous leukemia (AML) were involved in this study. Two out of twelve ALL and three out of seven T-ALL bone marrow (BM) cells were stimulated by IL-7 in 3H-Thymidine incorporation. In normal and AML BM cells, IL-7 had no stimulatory activity as in various leukemic cell lines. Two normal peripheral blood T-cells responded to IL-7 dose dependently. We have seen the effect of IL-7 to stimulate T-lineage cells but, for precise conclusion, further study using more purified samples will be needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tumor Cells, Cultured
/
Lymphocytes
/
Leukemia-Lymphoma, Adult T-Cell
/
Leukemia, Myeloid, Acute
/
Interleukin-4
/
Interleukin-7
/
Dose-Response Relationship, Drug
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
1993
Type:
Article
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