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Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids
Allergy, Asthma & Immunology Research ; : 116-125, 2017.
Article in English | WPRIM | ID: wpr-161592
ABSTRACT

PURPOSE:

Extrafine-particle inhaled corticosteroids (ICS) have greater small airway deposition than standard fine-particle ICS. We sought to compare asthma-related outcomes after patients initiated extrafine-particle ciclesonide or fine-particle ICS (fluticasone propionate or non-extrafine beclomethasone).

METHODS:

This historical, matched cohort study included patients aged 12-60 years prescribed their first ICS as ciclesonide or fine-particle ICS. The 2 cohorts were matched 11 for key demographic and clinical characteristics over the baseline year. Co-primary endpoints were 1-year severe exacerbation rates, risk-domain asthma control, and overall asthma control; secondary endpoints included therapy change.

RESULTS:

Each cohort included 1,244 patients (median age 45 years; 65% women). Patients in the ciclesonide cohort were comparable to those in the fine-particle ICS cohort apart from higher baseline prevalence of hospitalization, gastroesophageal reflux disease, and rhinitis. Median (interquartile range) prescribed doses of ciclesonide and fine-particle ICS were 160 (160-160) µg/day and 500 (250-500) µg/day, respectively (P<0.001). During the outcome year, patients prescribed ciclesonide experienced lower severe exacerbation rates (adjusted rate ratio [95% CI], 0.69 [0.53-0.89]), and higher odds of risk-domain asthma control (adjusted odds ratio [95% CI], 1.62 [1.27-2.06]) and of overall asthma control (2.08 [1.68-2.57]) than those prescribed fine-particle ICS. The odds of therapy change were 0.70 (0.59-0.83) with ciclesonide.

CONCLUSIONS:

In this matched cohort analysis, we observed that initiation of ICS with ciclesonide was associated with better 1-year asthma outcomes and fewer changes to therapy, despite data suggesting more difficult-to-control asthma. The median prescribed dose of ciclesonide was one-third that of fine-particle ICS.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / Gastroesophageal Reflux / Odds Ratio / Rhinitis / Prevalence / Cohort Studies / Adrenal Cortex Hormones / Disease Progression / Anti-Asthmatic Agents / Diethylpropion Type of study: Etiology study / Incidence study / Observational study / Prevalence study / Risk factors Limits: Humans Language: English Journal: Allergy, Asthma & Immunology Research Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Asthma / Gastroesophageal Reflux / Odds Ratio / Rhinitis / Prevalence / Cohort Studies / Adrenal Cortex Hormones / Disease Progression / Anti-Asthmatic Agents / Diethylpropion Type of study: Etiology study / Incidence study / Observational study / Prevalence study / Risk factors Limits: Humans Language: English Journal: Allergy, Asthma & Immunology Research Year: 2017 Type: Article